Preheat grill over medium heat until fully heated.
In a large mixer bowl mix together ground beef, salt, pepper, onion powder, garlic powder, 2 TBS prepared barbecue sauce, and egg until fully combined
Shape meat mixture into 4 quarter pound patties. Grill on preheated grill about 5-7 minutes on each side or until no pink
Remove from grill and immediately add a slice of cheese to each patty.
Spoon desired amount of barbecue sauce on each burger bun. Top each bun with a burger patty.
Top burger patties with additional toppings and barbecue sauce. Serve immediately